National Academies of Sciences Engineering and Medicine: Examining Glucagon-Like Peptide-1 Receptor (Glp-1r)..., Kartoniert / Broschiert

National Academies of Sciences Engineering and Medicine, Health And Medicine Division, Board On Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders

Examining Glucagon-Like Peptide-1 Receptor (Glp-1r) Agonists for Central Nervous System Disorders

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Proceedings of a Workshop

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Auswahl:: Sheena M Posey Norris, Eva Childers, Robert Pool
Verlag:: National Academies Press, 11/2025
Einband:: Kartoniert / Broschiert
Sprache:: Englisch
ISBN-13:: 9780309735056
Umfang:: 118 Seiten
Erscheinungstermin:: 27.11.2025
Hinweis: Achtung: Artikel ist nicht in deutscher Sprache!

Klappentext

Glucagon-like peptide-1 receptor (GLP-1R) agonists, originally developed for type 2 diabetes patients and popularized by their ability to rapidly reduce body weight in patients with obesity, have recently received a lot of national attention. Repurposing GLP-1R agonists to treat some central nervous disorders is promising, but comparatively understudied. At a September 2024 workshop, the National Academies Forum on Neuroscience and Nervous System Disorders reviewed the current knowledge and research gaps about the mechanisms of action of GLP-1R agonists in the brain, and the evidence of their clinical efficacy for eating disorders, neurodegenerative diseases, substance use disorders, and pain.