Advances in NADPH Oxidases Research: From Molecules to Diseases, Gebunden

Klappentext

This book provides an uptödate overview of the expanding roles of NADPH oxidases (Noxes) in human health and disease. Building on the earlier volume NADPH Oxidases Revisited: From Function to Structure, it shifts the focus toward the involvement of Nox enzymes in pathological mechanisms and their emerging relevance for therapeutic strategies.

The book highlights the chemistry and functions of Noxderived molecules, their roles in cytotoxic and signaling pathways, and the cooperation between Nox products and antioxidative defense systems in host tissues and pathogens. It also summarises recent advances in Nox biochemistry, synthesis and structural biology, illustrating how new mechanistic insights refine current models of enzyme activation and regulation.

Further chapters address the cell biology of Nox activity, including subcellular organisation and dynamic control within immune and nonimmune cells. A major section examines the contribution of Nox enzymes to a broad range of diseases---such as inflammation, cardiovascular and metabolic disorders, neurodegeneration, infections and cancer---and discusses the therapeutic potential of targeting Noxmediated pathways.

Three introductory essays portray the scientific contributions of key figures in the field, providing historical context and personal perspectives on the development of Nox research.

Advances in NADPH Oxidases Research brings together molecular, cellular and translational insights, offering a concise yet comprehensive resource for researchers and clinicians interested in the biology and medical relevance of NADPH oxidases.